ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Mantle Cell Lymphoma (MCL) Cells
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چکیده
منابع مشابه
ZGDHu-1 promotes apoptosis of mantle cell lymphoma cells
Mantle cell lymphoma (MCL) is a well-defined aggressive Non-Hodgkin-lymphoma with short survival rates and remains incurable to date. Previously, we demonstrated the antitumor activity of ZGDHu-1(N, N'-di-(m-methylphenyi)-3, 6-dimethyl-1, 4-dihydro-1, 2, 4, 5-tetrazine-1, 4-dicarboamide) in chronic lymphocytic leukemia. In this study, ZGDHu-1 shows potent anti-lymphoma activity in MCL cells. ZG...
متن کاملDiagnosis and prognosis of B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL) and mantle cell lymphoma (MCL).
BACKGROUND B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma (B-CLL/SLL) and mantle cell lymphoma (MCL) show many overlapping morphologic and immunophenotyping features, however they have great difference in therapeutic regimens and prognosis. THE AIM OF THE STUDY Is to determine the diagnostic and prognostic role of clinico-pathologic variables, CD23 and Cyclin D1 oncoprotiens ...
متن کاملBlockade of Fatty Acid Synthase Triggers Significant Apoptosis in Mantle Cell Lymphoma
Fatty acid synthase (FASN), a key player in the de novo synthetic pathway of long-chain fatty acids, has been shown to contribute to the tumorigenesis in various types of solid tumors. We here report that FASN is highly and consistently expressed in mantle cell lymphoma (MCL), an aggressive form of B-cell lymphoid malignancy. Specifically, the expression of FASN was detectable in all four MCL c...
متن کاملA novel gallium compound synergistically enhances bortezomib-induced apoptosis in mantle cell lymphoma cells.
Combination chemotherapy forms the backbone of cancer treatment. There is a need for new drug combinations for the treatment of mantle cell lymphoma (MCL). Herein, we show that gallium maltolate, a novel gallium compound, synergizes with bortezomib, a proteasome inhibitor, to induce cell death in MCL Granta cells. Cells exposed to either agent displayed caspase-3 activation, a loss of mitochond...
متن کاملmantle cell lymphoma 435 APOPTOSIS-RELATED GENES IDENTIFY POOR SURVIVAL GROUP AMONG MANTLE CELL LYMPHOMA PATIENTS
Materials/Method: To examine the relationship between BIM protein expression and genomic BIM loss, we performed Western blotting analysis using whole cell lysates of the seven MCL cell lines. This expression was compared to the results of array CGH, especially for the relationship with BCL2, the antagonist of BIM. In order to understand the relevance of apoptosis-related genes in MCL, published...
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ژورنال
عنوان ژورنال: Blood
سال: 2019
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2019-129773